Orthotopic CDX Models

Orthotopic mouse models play a pivotal role in cancer research and drug development. These models entail the implantation of tumor cells into a mouse's organ of origin, closely mirroring the natural tumor environment, thus providing better clinical predictivity than subcutaneous approaches. Orthotopic models faithfully replicate the primary tumor site, enabling more precise examination of tumor growth, interactions with stromal cells and immune elements, and disease progression, including metastasis.

LIDE has established over several luciferace-labeled models for use in your preclinical studies. We could also establish new orthotopic models complimentary if you can't find them elsewhere.

Cell Line / CDX

Source

Labeled

Model Availability

GL261

Murine glioblastoma cancer

N/A

Yes

U87-MG

Human glioblastoma cancer

Yes

Yes

HCT-116

Human colon cancer

Yes

Yes

Hep3B

Human liver cancer

Yes

Yes

HepG2

Human liver cancer

Yes

In Progress

A549

Human lung cancer

Yes

In Progress

K562

Human chronic myelogenous leukemia

Yes

In Plan

NALM-6

Human acute lymphoblastic leukemia

Yes

In Plan

Raji

Human Burkitts lymphoma

Yes

In Plan

Orthotopic models offer a highly relevant tumor microenvironment (TME) akin to the human disease scenario. This makes them exceptionally valuable for investigating disease mechanisms, testing novel therapeutics designed for the metastatic niche, and generating responses to anticancer agents that closely parallel clinical outcomes. They deliver superior preclinical predictability compared to subcutaneous alternatives and are an indispensable resource for advancing our knowledge of cancer and developing effective treatments. Explore the potential of orthotopic mouse models for comprehensive cancer research and therapeutic development.